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Platelet-Rich Plasma (PRP) is now being applied at the knee level, playing a central role in tissue, tendon, joint, muscle, and bone regeneration. Indeed, the medical world is becoming aware that traditional treatments (surgery, physiotherapy, etc.) lack effectiveness.
It is worth noting that in France, 30% of people between the ages of 65 and 75 suffer from knee osteoarthritis.
Tendinitis is also very common, especially among athletes (see article: PRP in sports), and like osteoarthritis, it is now treated with PRP.
PRP, a viable and effective solution
As a reminder, PRP injection increases the concentration of growth factors, accelerating the healing process by actively regenerating joints, tissues, cartilage, tendons, and muscles.
This observation applies to all knee problems such as osteoarthritis, tendinitis, or cartilage damage.
Cartilage, tendons, and ligaments are parts of the body that receive little blood supply. Consequently, they heal and scar slowly due to this weakened blood circulation.
In such circumstances, PRP emerges as an effective solution; the platelet injection will promote circulation in the blood vessels.
PRP, being rich in growth factors, helps damaged tissues heal. In addition to growth factors, platelets provide certain healthy elements. These include fibronectin, a glycoprotein that plays a role in cell adhesion to the extracellular matrix. Similarly, vitronectin, a glycoprotein found in blood plasma, promotes cell adhesion and migration.
Finally, sphingosine-1-phosphate, or S1P, is an important metabolite of sphingolipids. As a bioactive signaling molecule, S1P plays a crucial role in a wide range of cellular processes, including atherosclerosis, inflammation, immunity, tumorigenesis, and cell proliferation.
Recent studies, such as the one conducted by Malacca General Hospital in 2014 (published in the Official Journal of the Malaysian Orthopaedic Association and ASEAN Orthopaedic Association), reveal that the use of PRP is more effective in treating knee pain and osteoarthritis than other treatments such as hyaluronic acid injections.
How does the recovery process work?
Some tips after PRP injection in the knee:
- Apply ice to your knee for 20 minutes every two or three hours during the first three days to relieve any discomfort.
- Take a strong pain reliever such as Tylenol to reduce immediate pain. If Tylenol is not sufficient, a safe analgesic (acetaminophen) may be prescribed; consult your treating physician for such medications.
- Avoid Ibuprofen, as it may interfere with the effectiveness of PRP.
- Rest and avoid activities that put weight on the knee.
- You may need to use crutches or a walker for a few days to avoid putting weight on your knee.
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